Continuing from the first post in this series, let’s look at Makin and Orban de Xivry’s Statistical Mistake #3: Inflating the units of analysis. The issue: What is N? In other words, how many independent data points are there, for whatever statistical analysis one wants to do? N is often mistakenly made larger than it … Continue reading Comments on “Ten common statistical mistakes…”: #3
The steady stream of scientific articles with irreproducible results, shaky conclusions, and poor reasoning [1] is, thankfully, accompanied by attempts to do something about it. A few months ago, Tamar Makin and Jean-Jacques Orban de Xivry published an excellent short article called “Ten common statistical mistakes to watch out for when writing or reviewing a … Continue reading Comments on “Ten common statistical mistakes…”: #1 and #2
Given that all university classes are currently being run on-line due to the Covid-19 pandemic, our science teaching journal club topics for the term are mostly focused on remote instruction. Last week’s article [1] was a 2019 study comparing different methods for preparing video-based short lectures. It was especially interesting for reasons that can be … Continue reading Two graphs about on-line learning
About a new paper from my lab [1] on why gut bacteria swim, and whether their host cares. Many bacteria swim. It’s a great way to explore one’s surroundings, run away from toxins, or move toward regions with more food. Over the past several years, as we’ve used 3D microscopy to peer inside zebrafish to … Continue reading Putting the brakes on gut bacteria
Can the teardrops that fall after reading bad science writing generate renewable electricity? Yes, they can. 1. The puzzle of power from raindrops The usually excellent Marginal Revolution blog features daily “Assorted Links” that point to interesting articles on an exceptionally wide variety of topics, most often related to economics or sociology. Monday’s included a … Continue reading Can the teardrops that fall after reading bad science writing generate renewable electricity? Yes, they can.
About a new paper from my lab [1] on how membranes flow through water, featuring our shortest title ever! For many years I’ve been interested in the physical properties of cell membranes, properties determined in large part by the underlying lipid bilayer. Bilayers are remarkable materials, and my research group has measured characteristics such as … Continue reading Watching membranes do nothing
There is a deluge of research papers; it is impossible to keep up. Everyone knows this and tackles it in their own way — plowing either systematically or randomly through as many new publications as they can, or giving up and just searching for papers when needed. I think it’s important to be aware of … Continue reading Papers as noise
Synopsis: In a recent paper from my lab [1], we report on watching gut bacteria get pummeled by low doses of antibiotics. The antibiotics induce changes in the spatial organization of the microbes, with major consequences for their ability to persist in the gut. Motivations At high enough doses, antibiotic drugs will kill bacteria, or at … Continue reading An intestinal amplifier for antibiotics
For months I’ve been intending to write about a fascinating and frightening 2018 paper on the “half-life” of scientists — how long scientists remain in the scientific workforce. I was reminded of this recently by an excellent paper comparing the impact of small and large research groups on science. The two papers should perhaps be … Continue reading Science, Small Groups, and Stochasticity
Are there general laws governing the gut microbiome? This is an important question if we’re to make sense of how the microbial ecosystem inside each of us influences health and disease, without being overwhelmed by its diversity and complexity. It’s also the question that, almost verbatim, starts off a recent paper from my lab, … Continue reading Kepler, Newton, and Gut Microbes
The Eighteenth Elephant 