Synopsis: In a recent paper from my lab , we report on watching gut bacteria get pummeled by low doses of antibiotics. The antibiotics induce changes in the spatial organization of the microbes, with major consequences for their ability to persist in the gut. Motivations At high enough doses, antibiotic drugs will kill bacteria, or at … Continue reading An intestinal amplifier for antibiotics
I decided to make a version of the abstract for my upcoming presentation at the March Meeting of the American Physical Society that (i) has a movie, and (ii) is revised slightly from the version I submitted a few months ago. My talk is one of two invited talks at a pair of focus sessions … Continue reading Bacterial behaviors and the physical landscape of the zebrafish gut [APS talk abstract]
Are there general laws governing the gut microbiome? This is an important question if we’re to make sense of how the microbial ecosystem inside each of us influences health and disease, without being overwhelmed by its diversity and complexity. It’s also the question that, almost verbatim, starts off a recent paper from my lab, … Continue reading Kepler, Newton, and Gut Microbes
Synopsis: A blurb about a recent paper from my lab , on our discovery that the bacterium that causes cholera can manipulate the mechanical environment of an animal gut to expel resident bacteria. Introduction: cholera’s tools, and ours Cholera killed more people in the 19th century than any other epidemic disease, and it continues to … Continue reading New Tricks from an Old Bacterium
An extremely long post, mainly written to have something to point people to as a commentary on some recent work. A new paper from my lab came out recently in PLOS Biology, on watching and learning about the competition between gut microbes. I like the paper a lot, and, with one possible exception, it took more hard labor … Continue reading How are your intestines like a tide pool?