Each of us has a genome of about 3 billion DNA nucleotides — a sequence of 3 billion As, Cs, Gs, and Ts. Knowing what this sequence is, whether our own sequence or that of a bacterium, a barley plant, a baboon, or anything else, tells us about the repertoire of tools its genome encodes, … Continue reading How did we make reading genomes a million times cheaper? — What is biophysics? #18
Perhaps when blowing your nose, or the nose of a sick child, you’ve wondered where all this stuff comes from. How can one nose make so much mucus? This is #17 in our series of biophysical questions (#1, #16). The answer involves electrical forces and the physical character of mucus. Mucus, the gooey liquid secreted … Continue reading How can one nose make so much mucus? — What is biophysics? #17
Viruses encode their genomes in RNA or DNA, which they pack into a tiny space. For example, Varicella zoster, the virus that causes chickenpox and shingles, stuffs a double-stranded DNA molecule about 40,000 nm in length into a shell about 200 nm in diameter. This is even more impressive than it may seem because DNA … Continue reading Can viruses explode? — What is biophysics? #16
There’s a lot of advice out there for prospective applicants for academic faculty positions [1], so you don’t really need mine. However, some advice is outdated and some is incomplete, so I thought it would be worthwhile to add a small bit of information based on experiences from my department’s search last year (Physics, University … Continue reading Zoom Interview Questions and Other STEM Faculty Hiring Tidbits
Last Spring, I taught the second term of University of Oregon’s statistical mechanics / thermodynamics for physics majors course (syllabus). I might at some point describe how the course went and what lessons might be drawn, beyond the key lesson that statistical mechanics is a wonderful subject. For now, something far less substantial: I often … Continue reading Statistical Mechanics Has a Good Beat and You Can Dance To It
What makes one microscope better than another? A few weeks ago I co-ran a week-long Physics and Human Physiology day camp for high school students, part of the University of Oregon’s “SAIL” program that especially targets low-income students. I’ve written about SAIL before (2019, 2017, 2014) — this was our 14th Physics + Human Physiology … Continue reading A Few Flavors of Microscopes — SAIL recap, 2023
Biophysics is full of deep puzzles that are surprisingly simple to state. Imagine a pill shaped bacterium. (Your body is home to trillions.) It grows and then cleaves itself into two equally sized progeny. How does it know where its middle is? For us, looking at the bacterium, finding the middle is an easy task. … Continue reading How does a bacterium find its center? — What is biophysics? #15
The last seven books I read were all published in 1965. I decided on this literary time travel after noticing that I unintentionally read two books in a row from 1965. I thought: Why not continue? Would I get a deep sense of the mid-1960s zeitgeist? I don’t think so, but I did find two … Continue reading Reading Like It’s 1965
Suppose someone told you that they were deeply concerned about environmental issues, the consequences of fossil fuel use in particular, and that they would therefore take concrete action to reduce their energy footprint. The action: driving one mile per hour more slowly than usual — 54 rather than 55 mph. You would probably be unimpressed. … Continue reading If you care about the environment, and you don’t care about numbers, do you care about the environment?
I’ve taught several times a graduate course on biophysics, the first instance of which I blogged about here. I love teaching this class, and students seem fond of it as well. I’m teaching it again next Fall (2023) but with a twist: it will now be a combined undergraduate / graduate course. The motivations are … Continue reading Introduction to Biological Physics — an old and new course
The Eighteenth Elephant 